Organic Synthesis

ExperimentSynthesis[]

Robotic Milligram Scale Parallel Reactors

Reaction vessels with operation volumes from 0.5 to 125 mL
Automated liquid dispensing from 10 µL to 10 mL
Positive displacement pipettes for viscous liquids
Automated solid dispensing from 2 to 150 mg
Overhead stirring up to 750 RPM
In situ pH sensors
On-deck viscosity measurement
Operational temperature range from -55 to 180°C
Low oxygen and low moisture levels via nitrogen purge box

Gram Scale Jacketed Reactor

Reaction vessels with operation volumes from 50 mL to 5 L
Operational temperature range from -40 to 180°C
Temperature control achieved through jacket of heating/cooling fluid around reaction vessel
In situ temperature, pH, conductivity, Raman, and/or IR sensors
Automated dosing via syringe pump (30 µL/min to 200 mL/min)
Overhead stirring up to 1,000 RPM

Cryo Reactor

Operational temperature as low as -65ºC without use of any circulating cooling fluid, dry ice, or liquid nitrogen
Reaction vessels with operation volumes from 1 to 100 mL
In situ temperature, pH, conductivity, IR, and/or Raman sensors
Automated dosing via syringe pump (30 µL/min to 200 mL/min)
Overhead stirring up to 1,000 RPM

High Pressure Reactor

Stainless steel reaction vessels with operation volumes up to 100 mL
Operational temperature range from -20 to 200°C
Operational pressure up to 60 bar
In situ temperature and pressure sensors
Overhead stirring

Photochemical Reactor

18W LED Light source (365 nm, 425 nm or 450 nm)
Multiple vials at once (2 x 20 mL, 8 x 2 mL, 8 x 4 mL, 8 x 8 mL, 32 x 0.3 mL)
Reactions at 0°C – 80°C
Magnetic stirring

ExperimentFlowSynthesis[]

Flow Reactor

-70 to 250°C temperature range
20 µL/min to 10mL/min flow rate range
42 bar maximum reaction pressure
Tube and column reactors
In situ UV/Vis and IR measurement
Automated reagent loading and product collection
Photoreactors available in 220 to 600 nm wavelength range

ExperimentMicrowaveSynthesis[]

Microwave Reactor

900 W magnetron
Reaction durations up to 100 h
Up to 100 mL per reaction vial (10, 35, & 100 mL vessels)
21 Bar maximum operation pressure
300ºC maximum operation temperature
In situ temperature measurement with IR sensors
Autosampler with up to 48 (10 mL) or 24 (35 mL) vials

ExperimentElectrochemicalSynthesis[]

Electrochemical Reactor

Capable of running cyclic voltammetry, constant current, and constant potential experiments
Divided and undivided sample chambers available
Minimum voltage step of 10 mV
Voltage reading accurate to ± 16 mV
Current reading accurate to ± 6.2 µA
Various available electrodes (including glassy carbon, platinum, graphite, gold, and many others)
1 mL, 2 mL, 5 mL, 10 mL, and 20 mL reaction vessel sizes
Able to run up to 6 reaction vessels at once
Can stir reaction vessels from 50 to 1,500 RPM

ExperimentReactionCalorimetry[]

Reaction Calorimeter

10 to 1,000 mL usable reactor volume
Capable of measuring power as low as ± 0.1 W
Operational at isothermal, isoperibolic, constant or ramp heat flow, and temperature scanning modes
Stirring from 30 to 1,200 RPM
Capable of operating under difficult conditions such as reflux or at phase changes

ExperimentDNASynthesis[]

Example applications include: DNA Synthesis, DNA Modification, DNA, DNA Oligomers, Nucleotide Synthesis, Custom DNA, Bespoke DNA, Oligonucleotide Synthesis

ExperimentRNASynthesis[]

Example applications include: RNA, RNA Synthesis, Oligonucleotide Synthesis, Custom RNA Synthesis, Nucleotide Synthesis, Ribonucleic Acid Synthesis

Robotic DNS Synthesizer

Synthesis Columns

40 nmol, 200 nmol, or 1 μmol scale ABI columns
Standard or custom columns available
48x columns per batch

Reagents

8x standard phosphoramidate positions (standard or UltraMILD bases)
6x custom modification positions (any custom solution can be loaded)
Positive pressure based delivery and draining (argon)

Synthesis Cycle

Custom coupling times for each phosphoramidate and modification
Double coupling after a programmable number of cycles
Custom volumes and incubation durations available for each step in the cycle

Cleavage

Heated or room temperature incubation with any custom cleavage cocktail for any programmable duration
Purification by filter and washing (with programmable amounts of solvent)
Optional neutralization and/or speedvacing or lyophilization of product
Can leave strands uncleaved on support for further solid phase synthesis

ExperimentPeptideSynthesis[]

Example applications include: Peptide Synthesis, Custom Peptides, Solid Phase Peptide Synthesis, Solid Phase Synthesis

ExperimentPNA S ynthesis []

Example applications include: PNA, Peptide Nucleic Acid, Oligomer Synthesis, PNA Oligomer, Custom PNA

Robotic Peptide Synthesizer

Compatible with Fmoc coupling strategies
Customizable coupling times, reagent amounts, and cycles
Customizable cleavage conditions
Customizable reagents and monomers
Customizable resuspension conditions
Double coupling after n-monomers available
Pre-activation available
5 to 100 μmol scale

Reaction Vessels

Pressure push (nitrogen at 5 PSI) for flushing vessels
24x reaction vessels (12x with optional pre-activation)
10 mL vessels (~50 to 250 mg of resin) or 45 mL vessels (~50 mg to 1.125 g of resin)

Reagent Positions

Driven by nitrogen pressurization of source bottles
28x 400 mL monomer positions
8x reagent bottle positions (1 L or 4 L bottles)
20 L of dimethylformamide (DMF) or other solvent containers

ExperimentPCR[]

Automated Thermocycler

Temperature accuracy: ± 0.25°C (between 35.0 and 99.9°C)
Max block ramp rate: 3.5°C/sec
Max sample ramp rate: 1.8°C/sec
Temperature range: 4 to 105°C
Temperature uniformity: ± 0.50°C (20 sec after reaching 95°C)

Sample Constraints

Plate format: 96-well PCR plate
Sample volume: 10 to 100 µL

ExperimentSolidPhaseSynthesis[]

Example applications include: Compound Separation, Compound Purification, Mobile Phase, Solid Sorbent, Filtration

Small Robotic Liquid Handler