SCIENTIFIC INSTRUMENTATION
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ORGANIC SYNTHESIS
ExperimentSynthesis[]
Robotic Milligram Scale Parallel Reactors
- Reaction vessels with operation volumes from 0.5 to 125 mL
- Automated liquid dispensing from 10 µL to 10 mL
- Positive displacement pipettes for viscous liquids
- Automated solid dispensing from 2 to 150 mg
- Overhead stirring up to 750 RPM
- In situ pH sensors
- On-deck viscosity measurement
- Operational temperature range from -55 to 180°C
- Low oxygen and low moisture levels via nitrogen purge box


Gram Scale Jacketed Reactor
- Reaction vessels with operation volumes from 50 mL to 5 L
- Operational temperature range from -40 to 180°C
- Temperature control achieved through jacket of heating/cooling fluid around reaction vessel
- In situ temperature, pH, conductivity, Raman, and/or IR sensors
- Automated dosing via syringe pump (30 µL/min to 200 mL/min)
- Overhead stirring up to 1,000 RPM

Cryo Reactor
- Operational temperature as low as -65ºC without use of any circulating cooling fluid, dry ice, or liquid nitrogen
- Reaction vessels with operation volumes from 1 to 100 mL
- In situ temperature, pH, conductivity, IR, and/or Raman sensors
- Automated dosing via syringe pump (30 µL/min to 200 mL/min)
- Overhead stirring up to 1,000 RPM

High Pressure Reactor
- Stainless steel reaction vessels with operation volumes up to 100 mL
- Operational temperature range from -20 to 200°C
- Operational pressure up to 60 bar
- In situ temperature and pressure sensors
- Overhead stirring

Photochemical Reactor
- 18W LED Light source (365 nm, 425 nm or 450 nm)
- Multiple vials at once (2 x 20 mL, 8 x 2 mL, 8 x 4 mL, 8 x 8 mL, 32 x 0.3 mL)
- Reactions at 0°C – 80°C
- Magnetic stirring

ExperimentFlowSynthesis[]
Flow Reactor
- -70 to 250°C temperature range
- 20 µL/min to 10mL/min flow rate range
- 42 bar maximum reaction pressure
- Tube and column reactors
- In situ UV/Vis and IR measurement
- Automated reagent loading and product collection
- Photoreactors available in 220 to 600 nm wavelength range

ExperimentMicrowaveSynthesis[]
Microwave Reactor
- 900 W magnetron
- Reaction durations up to 100 h
- Up to 100 mL per reaction vial (10, 35, & 100 mL vessels)
- 21 Bar maximum operation pressure
- 300ºC maximum operation temperature
- In situ temperature measurement with IR sensors
- Autosampler with up to 48 (10 mL) or 24 (35 mL) vials

ExperimentElectrochemicalSynthesis[]
Electrochemical Reactor
- Capable of running cyclic voltammetry, constant current, and constant potential experiments
- Divided and undivided sample chambers available
- Minimum voltage step of 10 mV
- Voltage reading accurate to ± 16 mV
- Current reading accurate to ± 6.2 µA
- Various available electrodes (including glassy carbon, platinum, graphite, gold, and many others)
- 1 mL, 2 mL, 5 mL, 10 mL, and 20 mL reaction vessel sizes
- Able to run up to 6 reaction vessels at once
- Can stir reaction vessels from 50 to 1,500 RPM

ExperimentReactionCalorimetry[]
Reaction Calorimeter
- 10 to 1,000 mL usable reactor volume
- Capable of measuring power as low as ± 0.1 W
- Operational at isothermal, isoperibolic, constant or ramp heat flow, and temperature scanning modes
- Stirring from 30 to 1,200 RPM
- Capable of operating under difficult conditions such as reflux or at phase changes

ExperimentDNASynthesis[]
Example applications include: DNA Synthesis, DNA Modification, DNA, DNA Oligomers, Nucleotide Synthesis, Custom DNA, Bespoke DNA, Oligonucleotide Synthesis
ExperimentRNASynthesis[]
Example applications include: RNA, RNA Synthesis, Oligonucleotide Synthesis, Custom RNA Synthesis, Nucleotide Synthesis, Ribonucleic Acid Synthesis
Robotic DNS Synthesizer
Synthesis Columns
- 40 nmol, 200 nmol, or 1 μmol scale ABI columns
- Standard or custom columns available
- 48x columns per batch
Reagents
- 8x standard phosphoramidate positions (standard or UltraMILD bases)
- 6x custom modification positions (any custom solution can be loaded)
- Positive pressure based delivery and draining (argon)
Synthesis Cycle
- Custom coupling times for each phosphoramidate and modification
- Double coupling after a programmable number of cycles
- Custom volumes and incubation durations available for each step in the cycle
Cleavage
- Heated or room temperature incubation with any custom cleavage cocktail for any programmable duration
- Purification by filter and washing (with programmable amounts of solvent)
- Optional neutralization and/or speedvacing or lyophilization of product
- Can leave strands uncleaved on support for further solid phase synthesis

ExperimentPeptideSynthesis[]
Example applications include: Peptide Synthesis, Custom Peptides, Solid Phase Peptide Synthesis, Solid Phase Synthesis
ExperimentPNASynthesis[]
Example applications include: PNA, Peptide Nucleic Acid, Oligomer Synthesis, PNA Oligomer, Custom PNA
Robotic Peptide Synthesizer
- Compatible with Fmoc coupling strategies
- Customizable coupling times, reagent amounts, and cycles
- Customizable cleavage conditions
- Customizable reagents and monomers
- Customizable resuspension conditions
- Double coupling after n-monomers available
- Pre-activation available
- 5 to 100 μmol scale
Reaction Vessels
- Pressure push (nitrogen at 5 PSI) for flushing vessels
- 24x reaction vessels (12x with optional pre-activation)
- 10 mL vessels (~50 to 250 mg of resin) or 45 mL vessels (~50 mg to 1.125 g of resin)
Reagent Positions
- Driven by nitrogen pressurization of source bottles
- 28x 400 mL monomer positions
- 8x reagent bottle positions (1 L or 4 L bottles)
- 20 L of dimethylformamide (DMF) or other solvent containers

ExperimentPCR[]
Automated Thermocycler
- Temperature accuracy: ± 0.25°C (between 35.0 and 99.9°C)
- Max block ramp rate: 3.5°C/sec
- Max sample ramp rate: 1.8°C/sec
- Temperature range: 4 to 105°C
- Temperature uniformity: ± 0.50°C (20 sec after reaching 95°C)
Sample Constraints
- Plate format: 96-well PCR plate
- Sample volume: 10 to 100 µL

ExperimentSolidPhaseSynthesis[]
Example applications include: Compound Separation, Compound Purification, Mobile Phase, Solid Sorbent, Filtration
Small Robotic Liquid Handler
Synthesis Columns
- Up to 6x 3 cc or 6 cc columns per batch (loaded with any resin)
Synthesis Cycle
- Custom coupling times for addition
- Custom volumes and incubation durations available for each step in the cycle
Reagents
- 6x 500 mL reagent bottles (any custom solution can be loaded)
- 20x 12 mL reagent vials (any custom solution can be loaded)
- 1x system wash solvent (up to 20 L carboys)
- Positive pressure based delivery and draining (argon)

ExperimentBioconjugation[]
Example applications include: Chemical crosslinking, Protein modification, Antibody modification, Fluorophore conjugated, Biotinylated
Liquid Handler
- Low-volume chemical linking of biomolecules including microbeads, oligomers, proteins, and antibodies
- Utilizes all available solid transfer, liquid transfer, and mixing instrumentation
- Biomolecule activation can be specified prior to conjugation.
- Reaction quenching can be specified after conjugation
- Product workup including pelleting and filtering can be specified after conjugation
